Buy CJC-1295 No DAC
Buy CJC-1295 No DAC. Modified GRF 1-29 for GH research. ≥99% purity. Fast UK & EU delivery.
What is CJC-1295 No DAC?
CJC-1295 No DAC (also known as Modified GRF 1-29 or Mod GRF) is a synthetic analog of growth hormone-releasing hormone (GHRH) with specific amino acid modifications that enhance its stability and half-life. Unlike CJC-1295 with DAC, this version lacks the Drug Affinity Complex, producing pulsatile rather than sustained GH release patterns.
The peptide represents the first 29 amino acids of GHRH with modifications at positions 2, 8, 15, and 27 to improve resistance to enzymatic degradation. These modifications make it a more practical research tool while maintaining GHRH receptor binding activity.
Peptide Shop supplies research-grade CJC-1295 No DAC with guaranteed ≥99% purity, verified through comprehensive HPLC and mass spectrometry analysis.
How Does CJC-1295 No DAC Work?
GHRH Receptor Activation
The peptide binds to GHRH receptors on pituitary somatotropes:
- Gs protein coupling - Receptor-mediated signalling
- cAMP elevation - Adenylyl cyclase activation
- PKA activation - Downstream kinase cascade
- GH gene expression - Enhanced transcription
- GH release - Stimulated exocytosis
Modified Stability
Key substitutions provide enhanced stability:
- Position 2 - D-Ala substitution
- Position 8 - Gln to Ala
- Position 15 - Gly to Ala
- Position 27 - Met to Leu or Nle
Pulsatile vs Sustained Release
Without DAC, the peptide produces:
- Shorter half-life - Minutes rather than days
- Pulsatile GH patterns - Mimics physiology
- GHRP synergy - Enhanced when combined
Research Applications
GH Axis Studies
- GHRH signalling - Receptor pharmacology
- Pituitary function - Somatotrope biology
- GH pulsatility - Secretion pattern research
- Feedback mechanisms - Regulatory studies
Combination Research
- GHRP synergy - Enhanced GH release
- Ipamorelin combinations - Popular paradigm
- GHRP-6 studies - Comparative research
CJC-1295 No DAC Specifications
| Specification | Detail |
|---|---|
| CAS Number | 863288-34-0 |
| Molecular Weight | 3367.9 g/mol |
| Purity | ≥99% (HPLC) |
| Appearance | White lyophilised powder |
| Solubility | Soluble in water |
| Identity | Confirmed by mass spectrometry |
Storage
| Condition | Temperature | Duration |
|---|---|---|
| Lyophilised | -20°C | Up to 24 months |
| Reconstituted | 2-8°C | Up to 2-3 weeks |
Ordering Information
| Size | Recommended For |
|---|---|
| 2 mg | Pilot studies |
| 5 mg | Standard research |
Minimum order: £200 | 10% discount on orders over £200
Research Use Statement
For laboratory research only. Not intended for human or veterinary use.
Product Specifications
| CAS Number | 863288-34-0 |
|---|---|
| Molecular Weight | 3367.9 g/mol |
| Purity | ≥ 99% |
| Storage | -20°C recommended (research-only) |
| Available Sizes | 10 × 5 mg vials |
| Price Range | £250 per pack |
FAQ
CJC-1295 No DAC (Modified GRF 1-29) is used to study GHRH receptor activation and pulsatile growth hormone release. It's a modified GHRH analog with enhanced stability for research applications.
CJC-1295 without DAC (Mod GRF 1-29) has a shorter half-life and produces pulsatile GH release. CJC-1295 with DAC has Drug Affinity Complex for extended duration, producing sustained GH elevation.
It binds to GHRH receptors on pituitary somatotropes, stimulating cAMP production and GH release. The modifications at positions 2, 8, 15, and 27 provide enhanced stability.
Store lyophilised at -20°C. Once reconstituted, keep at 2-8°C and use within 2-3 weeks. The modifications improve but don't eliminate degradation.
Our CJC-1295 No DAC is ≥99% pure as verified by HPLC. Each batch includes a Certificate of Analysis with purity and mass spectrometry data.
Yes, researchers often study Mod GRF 1-29 with GHRPs like Ipamorelin or GHRP-6 to investigate GHRH-GHRP synergy. Both peptide types are available from Peptide Shop.
Reconstitute in sterile bacteriostatic water. Add solvent slowly along the vial wall and gently swirl to dissolve.
CJC-1295 No DAC is available in 2mg and 5mg vials.
Customer Reviews (15)
Based on 15 reviews
Dr. Helen Foster • 2024-12-12Verified Purchase
Our pituitary studies require high-quality GHRH analogs. Peptide Shop delivers excellent Mod GRF 1-29.
Cambridge GH Studies • 2024-12-05Verified Purchase
CJC-1295 quality is exceptional. Essential for our secretagogue combination research.
James Morrison • 2024-11-28Verified Purchase
Fast delivery, excellent quality. GHRH receptor binding studies working perfectly.
Edinburgh Endocrine Lab • 2024-11-21Verified Purchase
Consistent quality for our GHRH-GHRP synergy studies.
Dr. Robert Clarke • 2024-11-14Verified Purchase
Verified purity meets claims. Essential for growth hormone research.
Manchester Peptide Lab • 2024-11-07Verified Purchase
Fast delivery, great quality. The modifications provide good stability.
Sophie Williams • 2024-10-31Verified Purchase
Express delivery was prompt. Product quality excellent.
Oxford GH Research • 2024-10-24Verified Purchase
Quality is excellent for pulsatile GH release studies.
Dr. Catherine Moore • 2024-10-17Verified Purchase
Excellent for somatotrope signalling research.
Newcastle Hormone Lab • 2024-10-10Verified Purchase
Multiple orders, consistently excellent quality.
Michael Thompson • 2024-10-03Verified Purchase
Easy ordering, quality is good. Would appreciate larger sizes.
Glasgow Endocrine Studies • 2024-09-26Verified Purchase
High-quality Mod GRF with proper documentation.
Dr. Andrew Foster • 2024-09-19Verified Purchase
Research-grade quality for our combination studies.
Bristol GH Research • 2024-09-12Verified Purchase
Premium CJC-1295 for our receptor binding research.
Emma Richardson • 2024-09-05Verified Purchase
Quality peptide at a fair price. Essential for GH axis studies.
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