Buy Melanotan 2 UK
Buy Melanotan 2 UK. Premium MT-2 tanning peptide for melanogenesis research. ≥99% purity. Fast UK delivery.
What is Melanotan 2?
Melanotan 2 (MT-2, MT-II) is a synthetic cyclic heptapeptide analogue of alpha-melanocyte stimulating hormone (α-MSH). Originally developed at the University of Arizona in the 1980s, this research peptide has become an essential tool for studying melanocortin receptor signalling and the regulation of skin pigmentation.
The peptide’s cyclic lactam structure provides enhanced stability and receptor binding affinity compared to linear α-MSH analogues. Melanotan 2 acts as a non-selective agonist at melanocortin receptors MC1, MC3, MC4, and MC5, enabling researchers to study diverse physiological processes beyond pigmentation.
Peptide Shop supplies research-grade Melanotan 2 with guaranteed ≥99% purity, verified through comprehensive HPLC and mass spectrometry analysis. Each order includes a detailed Certificate of Analysis, ensuring researchers receive properly characterised material for their studies.
How Does Melanotan 2 Work?
Melanotan 2 exerts its biological effects through activation of melanocortin receptors, a family of G protein-coupled receptors that regulate diverse physiological processes. Understanding these mechanisms is central to ongoing research in dermatology, endocrinology, and neuroscience.
Melanocortin Receptor Family
MT-2 activates multiple melanocortin receptor subtypes:
- MC1R - Primarily expressed in melanocytes; regulates skin pigmentation
- MC3R - Expressed in hypothalamus and peripheral tissues; involved in energy homeostasis
- MC4R - Central nervous system expression; regulates appetite and sexual function
- MC5R - Sebaceous glands and other tissues; less well characterised
Melanogenesis Pathway
The primary research application involves studying skin pigmentation:
- MC1R activation - Triggers intracellular cAMP production in melanocytes
- MITF activation - Microphthalmia-associated transcription factor upregulation
- Tyrosinase expression - Key enzyme in melanin synthesis pathway
- Eumelanin production - Brown-black pigment providing UV protection
- Melanosome transfer - Distribution of pigment to keratinocytes
Central Nervous System Effects
MT-2’s non-selective receptor profile enables diverse CNS research:
- Appetite regulation - MC4R activation in hypothalamus suppresses food intake
- Energy expenditure - Effects on metabolic rate through central mechanisms
- Sexual behaviour - Research on erectile function and libido in animal models
- Anxiolytic effects - Studies on stress and anxiety-related behaviours
Anti-Inflammatory Research
Emerging research explores melanocortin anti-inflammatory properties:
- Cytokine modulation - Effects on inflammatory mediator production
- Immune cell function - Research on macrophage and lymphocyte behaviour
- Tissue protection - Studies on inflammation-related damage
Research Applications of Melanotan 2
Pigmentation Research
Melanotan 2 is extensively used in dermatological research:
- Melanogenesis mechanisms - Understanding pigment production pathways
- UV protection - Research on natural photoprotection
- Vitiligo models - Studies on repigmentation strategies
- Melanoma biology - Understanding MC1R role in melanocyte transformation
- Skin ageing - Research on photoprotection and pigmentary changes
Appetite and Obesity Research
MC4R activation makes MT-2 valuable for metabolic studies:
- Food intake regulation - Investigating central appetite control mechanisms
- Satiety signalling - Research on post-prandial fullness pathways
- Energy homeostasis - Studies on metabolic regulation
- Obesity models - Investigating potential intervention targets
Sexual Function Studies
Research into melanocortin effects on sexual behaviour:
- Erectile function - Studies on central arousal mechanisms
- Female sexual function - Research on desire and response pathways
- Receptor pharmacology - Understanding MC4R role in sexual behaviour
Inflammatory Disease Models
Anti-inflammatory properties are actively investigated:
- Arthritis models - Research on joint inflammation
- Inflammatory bowel disease - Studies on gut inflammation
- Neuroinflammation - Research on brain inflammatory conditions
- Tissue repair - Investigating healing in inflammatory contexts
Skin Disorder Research
Dermatological applications extend beyond pigmentation:
- Photoprotection mechanisms - Understanding skin UV defence
- Skin barrier function - Research on epidermal integrity
- Wound healing - Studies on melanocyte contribution to repair
Melanotan 2 vs Melanotan 1: Key Differences
Researchers often compare these related peptides:
| Feature | Melanotan 2 | Melanotan 1 |
|---|---|---|
| Structure | Cyclic heptapeptide | Linear tridecapeptide |
| Receptor Selectivity | Non-selective (MC1/3/4/5) | MC1R selective |
| Research Focus | Multiple applications | Pigmentation focused |
| CNS Effects | Significant | Minimal |
| Molecular Weight | 1024.2 g/mol | 1646.9 g/mol |
| Stability | High (cyclic) | Moderate (linear) |
Both peptides are available from Peptide Shop for comparative research studies.
Melanotan 2 Peptide Specifications
| Specification | Detail |
|---|---|
| CAS Number | 121062-08-6 |
| Molecular Formula | C₅₀H₆₉N₁₅O₉ |
| Molecular Weight | 1024.2 g/mol |
| Sequence | Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂ |
| Purity | ≥99% (HPLC) |
| Appearance | White to off-white lyophilised powder |
| Solubility | Freely soluble in water |
| Identity | Confirmed by mass spectrometry |
Reconstitution and Handling Guidelines
Reconstitution Protocol
Melanotan 2 is straightforward to prepare for research use:
- Allow vial to reach room temperature before opening
- Calculate desired concentration - common range is 1-2 mg/mL
- Add sterile bacteriostatic water slowly along the vial wall
- Gently swirl to dissolve - MT-2 dissolves readily
- Protect from light - MT-2 can degrade under prolonged light exposure
- Prepare aliquots if storing long-term
Storage Recommendations
| Condition | Temperature | Duration |
|---|---|---|
| Lyophilised | -20°C | Up to 36 months |
| Reconstituted | 2-8°C | Up to 4 weeks |
| Frozen aliquots | -20°C | Up to 6 months |
Stability note: The cyclic lactam structure provides excellent stability compared to linear peptides. However, protect from light and use standard peptide handling practices.
Why Choose Peptide Shop for Melanotan 2?
Guaranteed Purity
Every batch undergoes rigorous quality control:
- ≥99% purity by HPLC
- Identity confirmation by mass spectrometry
- Peptide content analysis
- Complete COA documentation
UK-Based Delivery
- Fast domestic shipping - No customs complications
- Next-day delivery available - For urgent research needs
- Temperature-controlled packaging - Maintains peptide quality
- Discreet, professional service - Secure delivery
Competitive Pricing
- Fair prices for research-grade quality
- 10% discount on orders over £200
- Bulk pricing available for institutions
Research Support
Our team provides:
- Reconstitution protocols
- Storage guidance
- Application advice
- Custom order enquiries
Ordering Melanotan 2 from Peptide Shop
Available Package Sizes
| Size | Recommended For |
|---|---|
| 10 mg | Standard research projects |
| 20 mg | Large-scale studies, extended research |
Bulk quantities available for institutional research.
Delivery Options
- Express UK Delivery (1-2 working days): £12.99
- Standard UK Delivery (3-5 working days): £5.99
Research Use Statement
This product is sold exclusively for laboratory research purposes. Melanotan 2 from Peptide Shop is not intended for human or veterinary use. It is for in vitro and animal research conducted by qualified professionals only.
Order Melanotan 2 Today
Advance your melanocortin research with premium-quality Melanotan 2. Our commitment to purity, documentation, and service supports your most demanding research applications.
Minimum order: £200 | 10% discount on orders over £200
Select your package size above and add to cart. Questions? Contact our team for assistance.
Product Specifications
| CAS Number | 121062-08-6 |
|---|---|
| Molecular Weight | 1024.2 g/mol |
| Purity | ≥ 99% |
| Storage | -20°C recommended (research-only) |
| Available Sizes | 10 × 10 mg vials |
| Price Range | £230 per pack |
FAQ
Melanotan 2 is primarily used in melanocortin receptor research, studying melanogenesis (skin pigmentation), appetite regulation, sexual function, and energy homeostasis. It's a non-selective agonist of melanocortin receptors MC1, MC3, MC4, and MC5.
Melanotan 1 (afamelanotide) is a linear peptide that selectively targets MC1 receptors for pigmentation research. Melanotan 2 is a cyclic peptide that non-selectively activates multiple melanocortin receptors, making it useful for broader research applications including appetite and sexual function studies.
Store lyophilised Melanotan 2 at -20°C for long-term stability. Once reconstituted, keep at 2-8°C and use within 4 weeks. The cyclic structure provides good stability, but protect from light and avoid repeated freeze-thaw cycles.
Our Melanotan 2 is ≥99% pure as verified by HPLC analysis. Each batch includes a Certificate of Analysis with purity data, mass spectrometry identity confirmation, and peptide content analysis.
Reconstitute Melanotan 2 in sterile bacteriostatic water. Add solvent slowly along the vial wall and gently swirl to dissolve. MT-2 dissolves readily in water. Common research concentrations range from 1-2 mg/mL.
Melanocortin receptors (MC1R-MC5R) are G protein-coupled receptors that regulate various physiological processes including pigmentation, appetite, inflammation, and sexual function. Melanotan 2 activates multiple receptor subtypes, making it valuable for diverse research applications.
MT-2 has good stability due to its cyclic lactam structure. Reconstituted peptide should be stored refrigerated (2-8°C) and used within 4 weeks. For longer storage, prepare aliquots and freeze at -20°C.
Melanotan 2 is available in 10mg and 20mg vials. These sizes are suitable for various research scales. Bulk quantities are available for institutional research - contact us for pricing.
Customer Reviews (24)
Based on 24 reviews
Dr. Karen Phillips • 2024-12-18Verified Purchase
Our pigmentation studies require high-quality MT-2. Peptide Shop delivers consistently - excellent purity and fast UK shipping. The COA documentation meets our quality requirements.
Newcastle Dermatology Lab • 2024-12-11Verified Purchase
We've tested several suppliers and Peptide Shop offers the best Melanotan 2 in terms of purity and value. Essential for our melanocyte research programme.
Steven Clark • 2024-12-05Verified Purchase
Ordered Monday, arrived Wednesday. Product quality is excellent - dissolves easily and shows expected receptor activation in our assays.
Edinburgh Melanocyte Studies • 2024-11-28Verified Purchase
Been ordering MT-2 for over a year. Consistent quality batch to batch is crucial for our long-term research. Peptide Shop delivers every time.
Dr. Thomas Reid • 2024-11-22Verified Purchase
Ran independent HPLC analysis - purity exceeds 99% as stated. Perfect for our melanogenesis pathway research. Highly recommended.
Manchester Skin Research • 2024-11-15Verified Purchase
After trying several suppliers, Peptide Shop offers the best combination of quality, price, and service. No more overseas shipping delays.
Rachel Thompson • 2024-11-08Verified Purchase
First order with Peptide Shop - impressed with the professionalism. MT-2 quality is excellent and customer service was helpful with my questions.
Oxford Pigmentation Lab • 2024-11-01Verified Purchase
Essential supplier for our melanocortin research. Quality is consistently high and the 20mg vials are great value for larger studies.
Dr. Amanda Foster • 2024-10-25Verified Purchase
Quality is excellent for research applications. Only minor feedback - would appreciate a 5mg size for smaller pilot studies.
Glasgow Cell Biology • 2024-10-18Verified Purchase
Our receptor binding studies depend on high-quality peptides. Peptide Shop MT-2 performs perfectly in our melanocortin assays.
David Morrison • 2024-10-12Verified Purchase
Quality MT-2 at a fair price. Fast UK delivery and excellent documentation. Will continue ordering from Peptide Shop.
Birmingham Endocrine Lab • 2024-10-05Verified Purchase
We use MT-2 for appetite regulation studies. Product quality is exceptional and results are highly reproducible.
Dr. Sophie Williams • 2024-09-28Verified Purchase
Multiple orders over several months - always excellent quality. Peptide Shop is our preferred supplier for melanocortin research.
Leeds Dermatology Research • 2024-09-22Verified Purchase
High-purity MT-2 that performs consistently. The COA documentation supports our research compliance requirements.
Michael Andrews • 2024-09-15Verified Purchase
Easy ordering, quick delivery, excellent quality. The 10% discount on larger orders is a nice bonus for our research budget.
Southampton Melanoma Research • 2024-09-08Verified Purchase
Our melanoma research requires reliable MT-2 supplies. Peptide Shop has been consistently excellent. Highly recommended.
Dr. Christopher Lee • 2024-09-01Verified Purchase
Verified purity in-house - matches claims perfectly. Essential for our melanocyte stimulation research. Great UK supplier.
Bristol Skin Biology • 2024-08-25Verified Purchase
We've standardised on Peptide Shop for all our melanocortin peptides. Consistent quality and professional service.
Emma Richardson • 2024-08-18Verified Purchase
Next-day delivery arrived as promised. Product was properly packaged and MT-2 quality is excellent.
Cardiff Pigmentation Lab • 2024-08-12Verified Purchase
High-quality MT-2 for our UV protection mechanism studies. Peptide Shop delivers reliable quality every time.
Dr. James Patterson • 2024-08-05Verified Purchase
Quality is very good for the price. Minor feedback: slightly faster delivery would be appreciated for urgent orders.
Liverpool Dermatology • 2024-07-30Verified Purchase
Excellent MT-2 quality and comprehensive documentation. Essential supplier for serious melanocortin research.
Nicole Edwards • 2024-07-25Verified Purchase
First time ordering research peptides - Peptide Shop made it easy. Product quality is excellent and customer service was helpful.
Cambridge Melanocyte Studies • 2024-07-20Verified Purchase
Our research demands high-purity peptides. Peptide Shop MT-2 consistently meets our quality standards. Highly recommended.
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