Buy Retatrutide UK
Buy Retatrutide UK. Triple GLP-1/GIP/Glucagon agonist for metabolic research. ≥99% purity. Fast UK delivery.
What is Retatrutide?
Retatrutide (LY3437943) is a novel synthetic peptide that functions as a triple agonist of three key metabolic receptors: glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon receptors. This unprecedented triple mechanism of action makes Retatrutide the most comprehensive incretin-based research tool currently available.
The peptide represents the next evolution beyond dual agonists like tirzepatide, adding glucagon receptor activation to the established GLP-1/GIP dual agonism. This triple receptor engagement enables researchers to study the complex interplay between these metabolic signalling systems and their combined effects on glucose homeostasis, energy expenditure, and body weight regulation.
Peptide Shop supplies research-grade Retatrutide with guaranteed ≥99% purity, verified through comprehensive HPLC and mass spectrometry analysis. Each order includes a detailed Certificate of Analysis, ensuring researchers receive properly characterised material for their studies.
How Does Retatrutide Work?
Retatrutide’s triple agonism creates a unique pharmacological profile by simultaneously engaging three complementary receptor systems, each contributing distinct metabolic effects.
GLP-1 Receptor Activation
The GLP-1 component provides established incretin effects:
- Glucose-dependent insulin secretion - Enhanced pancreatic beta-cell response
- Glucagon suppression - Reduced hepatic glucose output
- Appetite reduction - Central satiety signalling
- Gastric emptying delay - Prolonged nutrient absorption
GIP Receptor Activation
GIP receptor engagement adds complementary effects:
- Enhanced insulin secretion - Synergistic with GLP-1 effects
- Adipose tissue effects - Potential insulin sensitisation
- Beta-cell preservation - Supportive effects on islet function
- Bone metabolism - Research area of emerging interest
Glucagon Receptor Activation
The unique glucagon component provides:
- Thermogenesis - Increased energy expenditure
- Lipolysis - Enhanced fat mobilisation
- Hepatic effects - Altered glucose and lipid metabolism
- Appetite modulation - Additional satiety mechanisms
Synergistic Metabolic Effects
The triple combination creates unique research opportunities:
- Enhanced weight loss mechanisms - Multiple complementary pathways
- Improved metabolic flexibility - Coordinated fuel utilisation
- Hepatic lipid reduction - Potential effects on fatty liver
- Cardiovascular parameters - Emerging research focus
Research Applications of Retatrutide
Comparative Incretin Research
Retatrutide enables essential comparative studies:
- Mono vs dual vs triple agonism - Understanding receptor contribution
- Glucagon’s metabolic role - Separating from GLP-1/GIP effects
- Receptor selectivity - Optimising therapeutic profiles
Weight Management Studies
The triple agonist provides comprehensive weight research tools:
- Enhanced efficacy mechanisms - Understanding superior outcomes
- Thermogenic effects - Glucagon-mediated energy expenditure
- Appetite regulation - Multiple satiety pathways
- Body composition - Effects on fat vs lean mass
Hepatic Metabolism Research
Glucagon’s hepatic effects enable liver-focused studies:
- Hepatic lipid metabolism - NAFLD/NASH research applications
- Glucose production - Understanding hepatic glucose output
- Fatty acid oxidation - Studying lipid utilisation pathways
Energy Expenditure Studies
The thermogenic component opens unique research directions:
- Brown adipose tissue activation - Glucagon-mediated effects
- Metabolic rate changes - Understanding energy expenditure
- Cold-induced thermogenesis - Synergy with glucagon signalling
Retatrutide Peptide Specifications
| Specification | Detail |
|---|---|
| CAS Number | 2381089-83-2 |
| Molecular Weight | 4156.48 g/mol |
| Purity | ≥99% (HPLC) |
| Appearance | White to off-white lyophilised powder |
| Solubility | Soluble in water; alkaline buffer recommended |
| Identity | Confirmed by mass spectrometry |
Reconstitution and Handling
Reconstitution Protocol
- Equilibrate to room temperature before opening
- Add sterile bacteriostatic water or alkaline buffer slowly
- Gently swirl to dissolve - avoid shaking
- Prepare aliquots immediately for optimal stability
Storage Recommendations
| Condition | Temperature | Duration |
|---|---|---|
| Lyophilised | -20°C | Up to 24 months |
| Reconstituted | 2-8°C | Up to 3-4 weeks |
| Frozen aliquots | -20°C | Up to 3 months |
Why Choose Peptide Shop for Retatrutide?
Guaranteed Purity
- ≥99% purity by HPLC
- Mass spectrometry identity confirmation
- Comprehensive COA documentation
UK-Based Delivery
- Fast domestic shipping
- Next-day delivery available
- Temperature-controlled packaging
- No customs delays
Ordering Information
Available Sizes
| Size | Recommended For |
|---|---|
| 5 mg | Pilot studies |
| 10 mg | Standard research projects |
Minimum order: £200 | 10% discount on orders over £200
Research Use Statement
This product is sold exclusively for laboratory research purposes. Retatrutide from Peptide Shop is not intended for human or veterinary use.
Product Specifications
| CAS Number | 2381089-83-2 |
|---|---|
| Molecular Weight | 4156.48 g/mol |
| Purity | ≥ 99% |
| Storage | -20°C recommended (research-only) |
| Available Sizes | 10 × 5 mg vials |
| Price Range | £1800 per pack |
FAQ
Retatrutide is a triple agonist that activates GLP-1, GIP, and glucagon receptors simultaneously. This distinguishes it from dual agonists like tirzepatide (GIP/GLP-1) and mono-agonists like semaglutide (GLP-1 only), providing researchers a novel tool for studying multi-receptor metabolic effects.
Retatrutide is used in metabolic research to study triple receptor activation effects on glucose homeostasis, weight management, energy expenditure, hepatic lipid metabolism, and appetite regulation. The glucagon component adds unique thermogenic and lipolytic research applications.
Store lyophilised Retatrutide at -20°C for optimal stability. Once reconstituted, keep at 2-8°C and use within 3-4 weeks. Avoid repeated freeze-thaw cycles and protect from light exposure.
Our Retatrutide is ≥99% pure as verified by HPLC analysis. Each batch includes a Certificate of Analysis with purity data, mass spectrometry identity confirmation, and peptide content analysis.
The glucagon receptor agonism provides unique research opportunities in studying hepatic glucose production, thermogenesis, lipolysis, and energy expenditure mechanisms not achievable with GLP-1/GIP dual agonists alone.
Retatrutide has an extended half-life of approximately 6 days due to fatty acid modifications that enable albumin binding. This allows researchers to study sustained triple receptor activation effects.
Reconstitute in sterile bacteriostatic water or slightly alkaline buffer (pH 7.4-8.0). Add solvent slowly along the vial wall and gently swirl to dissolve. Avoid shaking vigorously.
Retatrutide is available in 5mg and 10mg vials. Larger quantities are available for institutional research projects - contact us for bulk pricing.
Customer Reviews (15)
Based on 15 reviews
Dr. Elizabeth Hayes • 2024-12-16Verified Purchase
We're studying the unique glucagon component effects and Peptide Shop delivers exceptional quality. The purity is verified and results are highly reproducible.
Bristol Metabolic Research • 2024-12-10Verified Purchase
Difficult to source reliable Retatrutide in the UK. Peptide Shop solved this with excellent purity and fast delivery. Essential for our comparative studies.
James Morrison • 2024-12-03Verified Purchase
First order of Retatrutide - impressed with the quality. COA documentation is comprehensive and peptide performed as expected.
Cambridge Triple Agonist Lab • 2024-11-26Verified Purchase
We've tested multiple suppliers. Peptide Shop offers the best Retatrutide quality and the most reliable service. Highly recommended.
Dr. Robert Mitchell • 2024-11-19Verified Purchase
Excellent purity and activity in our assays. Only 4 stars because we'd appreciate a smaller 2mg size for initial pilot studies.
Manchester Endocrine Lab • 2024-11-12Verified Purchase
The triple agonist profile provides unique research opportunities. Quality from Peptide Shop is consistently excellent.
Sophie Andrews • 2024-11-05Verified Purchase
Express delivery arrived next day. Product quality excellent. Will definitely order again for our research programme.
Edinburgh Obesity Studies • 2024-10-29Verified Purchase
Excellent for studying glucagon-mediated effects alongside incretin signalling. Quality is research-grade throughout.
Dr. Catherine Moore • 2024-10-22Verified Purchase
Our comparative studies between mono, dual, and triple agonists require high-quality peptides. Peptide Shop delivers consistently.
Newcastle Metabolism Lab • 2024-10-15Verified Purchase
Been ordering from Peptide Shop for several months. Retatrutide quality is always excellent. Great documentation.
Michael Thompson • 2024-10-08Verified Purchase
Independent HPLC confirmed purity above 99%. Perfect for serious metabolic research. Fair pricing too.
Oxford Incretin Research • 2024-10-01Verified Purchase
Essential for our multi-receptor studies. Peptide Shop provides the quality and documentation we need.
Dr. Andrew Foster • 2024-09-24Verified Purchase
Premium quality Retatrutide with comprehensive COA. Our research results align with published literature.
Glasgow Metabolic Unit • 2024-09-17Verified Purchase
Quality is excellent. Service was good. Minor feedback - faster customer service response would be appreciated.
Laura Bennett • 2024-09-10Verified Purchase
Easy ordering, fast delivery, excellent product. The 10mg size is perfect for our research scale.
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