Buy Semaglutide UK
Premium Semaglutide UK. Long-acting GLP-1 receptor agonist for weight loss research. Fast UK delivery. Lab verified ≥99% purity.
What is Semaglutide?
Semaglutide is a synthetic analogue of human Glucagon-Like Peptide-1 (GLP-1), a hormone naturally produced in the intestines that plays a crucial role in glucose metabolism and appetite regulation. This research peptide has gained significant attention in scientific communities worldwide for its applications in metabolic research, particularly in studies related to type 2 diabetes and obesity. For comprehensive background information, see the PubChem compound entry for Semaglutide{:target=“_blank” rel=“noopener”}.
The molecular structure of Semaglutide features a unique C-18 fatty diacid chain attached to the lysine residue at position 26. This structural modification enables the peptide to bind to serum albumin, dramatically extending its biological half-life to approximately seven days. This prolonged activity profile makes Semaglutide an invaluable tool for researchers studying sustained GLP-1 receptor activation mechanisms.
Peptide Shop supplies research-grade Semaglutide with guaranteed ≥99% purity, verified by HPLC analysis and mass spectrometry. Every order includes a comprehensive Certificate of Analysis (COA), ensuring researchers receive properly characterised material for their studies.
How Does Semaglutide Work?
Semaglutide exerts its biological effects through high-affinity binding to the GLP-1 receptor (GLP-1R), a G protein-coupled receptor expressed in various tissues including pancreatic beta cells, the central nervous system, heart, and gastrointestinal tract. Upon receptor binding, Semaglutide initiates several downstream signalling cascades that researchers continue to investigate.
Pancreatic Effects
In pancreatic beta cells, GLP-1 receptor activation by Semaglutide triggers glucose-dependent insulin secretion through the cAMP-PKA signalling pathway. This glucose-dependent mechanism is particularly noteworthy in research, as it suggests reduced risk of hypoglycaemia compared to insulin secretagogues that work independently of glucose levels.
Research has demonstrated that Semaglutide may also promote beta-cell proliferation and reduce apoptosis in preclinical models, suggesting potential applications in studying beta-cell preservation strategies.
Central Nervous System Actions
Semaglutide crosses the blood-brain barrier and activates GLP-1 receptors in key hypothalamic regions involved in appetite regulation, including the arcuate nucleus and paraventricular nucleus. Research indicates that this central action contributes to reduced food intake and altered food preferences in animal models.
Emerging research also explores Semaglutide’s potential neuroprotective properties, with studies investigating its effects in models of Alzheimer’s disease, Parkinson’s disease, and stroke.
Gastrointestinal Effects
GLP-1 receptor activation slows gastric emptying, which may contribute to prolonged satiety and reduced postprandial glucose excursions. Researchers studying gut-brain axis signalling find Semaglutide particularly useful for investigating these gastrointestinal regulatory mechanisms.
Research Applications of Semaglutide
Metabolic Research
Semaglutide is extensively used in metabolic research laboratories studying:
- Glucose homeostasis mechanisms - Understanding how GLP-1 receptor activation influences blood glucose regulation
- Insulin secretion dynamics - Investigating the molecular pathways governing glucose-dependent insulin release
- Beta-cell biology - Studying potential regenerative and protective effects on pancreatic beta cells
- Glucagon suppression - Researching the relationship between GLP-1 signalling and alpha-cell function
Weight Management Studies
The peptide’s effects on body weight have made it crucial for obesity research, including studies on:
- Appetite regulation - Investigating central mechanisms controlling food intake and satiety
- Energy expenditure - Studying metabolic rate changes associated with GLP-1 receptor activation
- Food preference alteration - Researching how GLP-1 signalling affects dietary choices in animal models
- Adipose tissue biology - Understanding effects on fat storage and metabolism
Cardiovascular Research
Emerging evidence suggests GLP-1 receptor agonists may have cardiovascular effects beyond glucose control, leading to research investigating:
- Endothelial function - Studying vasodilatory and anti-inflammatory properties
- Cardiac metabolism - Investigating effects on myocardial glucose and fatty acid utilisation
- Atherosclerosis progression - Researching potential anti-atherogenic mechanisms
Neuroscience Applications
The presence of GLP-1 receptors in the brain has sparked significant neuroscience research using Semaglutide:
- Neurodegeneration models - Investigating potential protective effects in Alzheimer’s and Parkinson’s disease models
- Stroke recovery - Studying effects on neuronal survival and functional recovery
- Cognitive function - Researching impacts on learning and memory in animal models
Semaglutide Peptide Specifications
Our research-grade Semaglutide meets the highest quality standards required for reproducible scientific research:
| Specification | Detail |
|---|---|
| CAS Number | 910463-68-2 |
| Molecular Formula | C₁₈₇H₂₉₁N₄₅O₅₉ |
| Molecular Weight | 4113.58 g/mol |
| Sequence | Modified GLP-1 (7-37) with Aib at position 8 and C-18 fatty diacid at Lys-26 |
| Purity | ≥99% (HPLC) |
| Appearance | White to off-white lyophilised powder |
| Solubility | Soluble in water at pH >7.0; slightly alkaline buffer recommended |
| Identity | Confirmed by mass spectrometry |
Reconstitution and Handling Guidelines
Reconstitution Protocol
For optimal results in research applications, follow these reconstitution guidelines:
- Allow the vial to reach room temperature before opening to prevent moisture condensation on the lyophilised peptide
- Calculate the required concentration for your research application
- Use sterile bacteriostatic water or a slightly alkaline buffer (pH 7.4-8.0) as the reconstitution vehicle
- Add the solvent slowly along the vial wall, not directly onto the peptide
- Gently swirl the vial to dissolve - never shake vigorously as this may cause peptide degradation
- Ensure complete dissolution before aliquoting for experiments
Storage Recommendations
| Condition | Storage Temperature | Recommended Duration |
|---|---|---|
| Lyophilised | -20°C | Up to 24 months |
| Reconstituted | 2-8°C | Up to 4 weeks |
| Working aliquots | -20°C | Up to 3 months |
Important considerations:
- Avoid repeated freeze-thaw cycles
- Protect from light during storage
- Store in airtight containers to prevent moisture absorption
- Use sterile technique during handling
Why Choose Peptide Shop for Semaglutide?
Guaranteed Purity
Every batch of our Semaglutide undergoes rigorous quality control testing. Our ≥99% purity guarantee is verified by HPLC analysis, with identity confirmed through mass spectrometry. We provide comprehensive documentation so you can trust the quality of your research materials.
UK-Based Supplier
As a UK-based peptide supplier, we offer significant advantages for British researchers:
- No customs delays - Fast domestic shipping without import complications
- Next-day delivery available - Urgent research needs addressed promptly
- Proper cold chain shipping - Temperature-controlled delivery to maintain peptide integrity
- Discreet packaging - Professional, unmarked packaging for all orders
Comprehensive Documentation
Each order includes a Certificate of Analysis (COA) providing:
- HPLC purity data and chromatograms
- Mass spectrometry confirmation
- Peptide content analysis
- Batch-specific information
Dedicated Support
Our technical team understands research peptides and can assist with:
- Reconstitution protocols
- Storage guidance
- Application advice
- Custom order enquiries
Ordering Semaglutide from Peptide Shop
Available Package Sizes
| Size | Ideal For |
|---|---|
| 2 mg | Pilot studies, initial testing, small-scale experiments |
| 5 mg | Standard research projects, method development |
| 10 mg | Large-scale studies, long-term research programmes |
Bulk quantities are available for institutional research projects - contact us for custom pricing.
Delivery Options
- Express UK Delivery (1-2 working days): £12.99
- Standard UK Delivery (3-5 working days): £5.99
All orders are shipped with appropriate cold packs to maintain peptide stability.
Important Research Use Notice
This product is sold exclusively for laboratory research purposes. Semaglutide from Peptide Shop is not intended for human or veterinary use, food additives, drug applications, or household purposes. Researchers are responsible for complying with all applicable regulations regarding the purchase and use of research materials.
This product is not “Ozempic”, “Wegovy”, or any other branded pharmaceutical. It is the raw research chemical Semaglutide, intended solely for in vitro and animal research applications conducted by qualified research professionals.
Order Semaglutide Today
Ready to advance your metabolic research with premium-quality Semaglutide? Peptide Shop provides the purity, documentation, and service that serious researchers demand.
Minimum order: £200 | Orders over £200 receive 10% discount automatically
Select your preferred package size above and add to cart to begin your order. Questions? Our team is ready to assist with your research peptide needs.
Product Specifications
| CAS Number | 910463-68-2 |
|---|---|
| Molecular Weight | 4113.58 g/mol |
| Purity | ≥ 99% |
| Storage | -20°C recommended (research-only) |
| Available Sizes | 1 month supply |
| Price Range | £200 per month |
FAQ
Semaglutide is primarily used in metabolic research to study GLP-1 receptor activation, glucose-dependent insulin secretion, appetite regulation, and weight management mechanisms. Research applications include investigating beta-cell function, gastric emptying rates, and potential neuroprotective properties in disease models.
Lyophilised Semaglutide should be stored at -20°C for long-term stability. Once reconstituted, store at 2-8°C (refrigerator) and use within 4 weeks. Avoid repeated freeze-thaw cycles and protect from light. Always store in airtight containers to prevent moisture absorption.
Our Semaglutide is ≥99% pure as verified by HPLC analysis. Each batch comes with a Certificate of Analysis (COA) confirming purity, identity via mass spectrometry, and peptide content. We maintain strict quality control throughout manufacturing and shipping.
Reconstitute Semaglutide in sterile bacteriostatic water or a slightly alkaline buffer (pH 7.4-8.0). Semaglutide can be difficult to dissolve in pure water near its isoelectric point. Gently swirl the vial rather than shaking vigorously to prevent peptide degradation.
No. Ozempic and Wegovy are brand-name prescription medications containing semaglutide as the active pharmaceutical ingredient. Our product is the raw research-grade peptide sold exclusively for laboratory research purposes, not for human consumption or medical treatment.
Semaglutide has an extended half-life of approximately 7 days due to its C-18 fatty diacid modification that promotes albumin binding. This prolonged half-life makes it particularly valuable for studying sustained GLP-1 receptor activation in research models.
We primarily offer fast UK delivery with next-day and standard shipping options. For international shipping enquiries, please contact our customer service team to discuss options and regulations for your specific country.
Semaglutide is available in 2mg, 5mg, and 10mg vials to suit various research needs and budgets. Larger quantities are available for institutional research projects - contact us for bulk pricing and custom orders.
Customer Reviews (25)
Based on 25 reviews
Dr. James Mitchell • 2024-12-15Verified Purchase
We've been using Peptide Shop' Semaglutide for our diabetes research programme for six months now. The consistency between batches is remarkable, and the COA documentation makes our compliance reporting straightforward. Highly recommended for serious research.
Sarah Thompson • 2024-12-10Verified Purchase
Ordered on Monday, received on Wednesday. The packaging was discrete and professional. The peptide dissolved easily and showed expected activity in our assays. Will definitely order again.
Research Lab Manchester • 2024-12-05Verified Purchase
After trying several suppliers, Peptide Shop offers the best combination of purity, price, and service. The £200 minimum is reasonable for research quantities, and the 10% discount helps our budget.
Dr. Emily Watson • 2024-11-28Verified Purchase
The Semaglutide quality is excellent - matches our reference standards perfectly. One vial had a slightly loose cap, but the product was unaffected. Customer service was helpful when I mentioned it.
Cambridge BioSciences • 2024-11-20Verified Purchase
We've placed multiple orders over the past year and the quality has been consistently high. The COA is always included and accurate. Our GLP-1 receptor binding assays show reproducible results.
Michael Chen • 2024-11-15Verified Purchase
Ran our own HPLC analysis and confirmed >99% purity as stated. Few suppliers match this level of transparency. Excellent for our appetite regulation studies.
Southampton Research Group • 2024-11-10Verified Purchase
Needed 50mg for a major study - they accommodated our bulk order with a reasonable lead time. Communication was excellent throughout.
Dr. Robert Hayes • 2024-11-05Verified Purchase
Quality is definitely there - our results are consistent with published literature. Would love to see even smaller package sizes for initial pilot studies.
Leeds University Lab • 2024-10-30Verified Purchase
The whole process was smooth. Website is easy to use, payment was secure, and delivery was tracked. Product arrived in perfect condition with dry ice.
Hannah Morris • 2024-10-25Verified Purchase
Had questions about reconstitution protocols and their team provided detailed guidance. The peptide performed exactly as expected in our glucose tolerance studies.
Bristol Metabolic Research • 2024-10-20Verified Purchase
We've compared Peptide Shop against three other UK suppliers. They win on purity, documentation, and delivery speed. Slightly higher price but worth it for the quality assurance.
Dr. Andrew Collins • 2024-10-15Verified Purchase
Running long-term studies requires consistent peptide quality. Peptide Shop has delivered this for our 12-month research programme without any issues.
Newcastle Biotech • 2024-10-10Verified Purchase
Competitive pricing for UK-based research peptides. The 10mg size is ideal for our throughput. Would recommend to colleagues.
Laura Bennett • 2024-10-05Verified Purchase
High-quality Semaglutide at a fair price. The express delivery option was perfect when we needed to meet our project deadline.
Edinburgh Cell Biology • 2024-09-30Verified Purchase
Glad to have found a quality UK supplier for research peptides. Avoids the customs delays we experienced with overseas orders. Product quality is excellent.
Dr. Victoria Adams • 2024-09-25Verified Purchase
Using this Semaglutide in our diet-induced obesity studies. Results align perfectly with published data using pharmaceutical-grade material.
Oxford Molecular Lab • 2024-09-20Verified Purchase
The quality justifies the investment. Our mass spec analysis confirmed identity and purity. Excellent for rigorous research applications.
Thomas Wright • 2024-09-15Verified Purchase
Ordered the 5mg size first to test quality. Impressed enough to place a larger follow-up order. Delivery was prompt and product was as described.
Glasgow Medical Research • 2024-09-10Verified Purchase
Outstanding product for our insulin secretion studies. The technical team was helpful with protocol questions. Highly recommend Peptide Shop.
Jennifer Clark • 2024-09-05Verified Purchase
Next-day delivery arrived before noon. Peptide was properly packaged with cold packs. Performed flawlessly in our receptor binding assays.
Birmingham Research Centre • 2024-09-01Verified Purchase
We've standardised on Peptide Shop for all our GLP-1 research needs. Consistent quality, reliable supply, and excellent documentation for our quality systems.
Dr. Peter Morgan • 2024-08-28Verified Purchase
Independent analysis confirmed the stated purity. Very few suppliers provide this level of quality for research-grade peptides in the UK market.
Cardiff University Lab • 2024-08-22Verified Purchase
The COA is comprehensive - HPLC, MS data, amino acid analysis. Exactly what we need for our research protocols. Product quality matches the documentation.
Alice Henderson • 2024-08-15Verified Purchase
Quality is excellent for the price point. The minimum order requirement is reasonable for lab-scale research. Would recommend trying the 2mg size first.
Liverpool Metabolic Studies • 2024-08-10Verified Purchase
Been searching for a reliable UK source for GLP-1 peptides. Peptide Shop delivers on quality, documentation, and customer service. Our new preferred supplier.
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