Buy Tirzepatide UK
Buy Tirzepatide UK. Dual GIP/GLP-1 receptor agonist for weight loss research. ≥99% purity verified. Fast UK delivery.
What is Tirzepatide?
Tirzepatide is a novel synthetic peptide that functions as a dual agonist of two key incretin hormone receptors: glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). This unique dual mechanism of action distinguishes Tirzepatide from single-target GLP-1 receptor agonists like semaglutide, making it an invaluable tool for metabolic research.
The peptide’s structure incorporates a modified GIP sequence with carefully engineered amino acid substitutions and a C20 fatty diacid side chain attached to lysine. This modification enables binding to serum albumin, extending the biological half-life to approximately five days and allowing researchers to study sustained dual receptor activation.
Peptide Shop supplies research-grade Tirzepatide with guaranteed ≥99% purity, verified through comprehensive HPLC and mass spectrometry analysis. Each order includes a detailed Certificate of Analysis to ensure researchers receive properly characterised material for their studies.
How Does Tirzepatide Work?
Tirzepatide exerts its biological effects through simultaneous activation of GIP and GLP-1 receptors, both of which are G protein-coupled receptors expressed in various metabolically active tissues. This dual agonism creates synergistic signalling effects that researchers continue to characterise.
Dual Incretin Receptor Activation
The GIP receptor is predominantly expressed in pancreatic beta cells and adipose tissue, while GLP-1 receptors are found in pancreatic islets, brain, heart, and gastrointestinal tract. By activating both receptor systems simultaneously, Tirzepatide provides researchers with a unique tool for studying:
- Synergistic insulin secretion - Combined GIP and GLP-1 signalling enhances glucose-dependent insulin release beyond what either hormone achieves alone
- Enhanced metabolic effects - Dual activation may improve insulin sensitivity through mechanisms distinct from single-agonist peptides
- Improved weight outcomes - Research suggests the dual mechanism may provide superior weight loss effects compared to GLP-1 mono-agonists
Pancreatic Beta-Cell Effects
In pancreatic beta cells, Tirzepatide activates both GIP and GLP-1 receptors, leading to:
- Enhanced cAMP production through dual receptor stimulation
- Improved glucose sensing and insulin granule exocytosis
- Potential beta-cell protective effects under metabolic stress conditions
- Reduced glucagon secretion from pancreatic alpha cells
Central Nervous System Actions
Like GLP-1 agonists, Tirzepatide affects appetite regulation through central mechanisms. Research indicates effects on:
- Hypothalamic appetite centres - Modulating food intake signalling
- Reward pathway activity - Potentially influencing food preferences
- Gastric emptying rates - Contributing to prolonged satiety
Adipose Tissue Effects
The GIP receptor component may provide unique effects on adipose tissue:
- Enhanced lipid metabolism - GIP signalling influences adipocyte function
- Improved insulin sensitivity - Fat tissue-specific effects may contribute to metabolic improvements
- Altered adipokine secretion - Potential effects on adiponectin and leptin
Research Applications of Tirzepatide
Comparative Incretin Research
Tirzepatide enables crucial comparative studies between:
- Single GLP-1 receptor agonists vs dual GIP/GLP-1 agonism
- GIP receptor-specific effects in metabolic regulation
- Receptor selectivity profiles and their physiological consequences
Metabolic Syndrome Studies
The dual agonist is valuable for investigating:
- Multi-organ metabolic coordination - Understanding how dual incretin signalling affects whole-body metabolism
- Insulin resistance mechanisms - Studying potential improvements in peripheral insulin sensitivity
- Hepatic glucose production - Investigating effects on liver metabolism
Weight Management Research
Tirzepatide’s superior weight outcomes in preclinical models make it essential for:
- Appetite regulation studies - Comparing dual vs single agonist effects on food intake
- Energy expenditure research - Investigating metabolic rate changes
- Adipose tissue biology - Understanding fat mass reduction mechanisms
Cardiovascular Research
Emerging areas of investigation include:
- Cardiac metabolism - Effects on myocardial glucose and lipid utilisation
- Vascular function - Potential endothelial effects of dual agonism
- Blood pressure regulation - Understanding cardiovascular impacts
Diabetes Research
Core applications in diabetes studies include:
- Beta-cell preservation - Investigating protective effects on insulin-producing cells
- Glucose homeostasis - Studying blood glucose regulation mechanisms
- Incretin physiology - Understanding the incretin effect in normal and diabetic states
Tirzepatide vs Semaglutide: Key Research Differences
| Feature | Tirzepatide | Semaglutide |
|---|---|---|
| Receptor Targets | GIP + GLP-1 (dual) | GLP-1 only |
| Half-life | ~5 days | ~7 days |
| Molecular Weight | 4813.45 g/mol | 4113.58 g/mol |
| Fatty Acid Modification | C20 diacid | C18 diacid |
| Research Focus | Dual incretin synergy | GLP-1 specific mechanisms |
Both peptides are available from Peptide Shop in research-grade purity, allowing direct comparison studies.
Tirzepatide Peptide Specifications
| Specification | Detail |
|---|---|
| CAS Number | 2023788-19-2 |
| Molecular Formula | C₂₂₅H₃₄₈N₄₈O₆₈ |
| Molecular Weight | 4813.45 g/mol |
| Purity | ≥99% (HPLC) |
| Appearance | White to off-white lyophilised powder |
| Solubility | Soluble in water; may require gentle warming |
| Identity | Confirmed by mass spectrometry |
Reconstitution and Handling Guidelines
Reconstitution Protocol
- Equilibrate to room temperature before opening the vial
- Calculate required concentration based on your experimental design
- Add sterile bacteriostatic water slowly along the vial wall
- Gently swirl to dissolve - avoid shaking
- Allow complete dissolution before use
- Aliquot immediately to avoid repeated freeze-thaw cycles
Storage Recommendations
| Condition | Temperature | Duration |
|---|---|---|
| Lyophilised | -20°C | Up to 24 months |
| Reconstituted | 2-8°C | Up to 4 weeks |
| Working aliquots | -20°C | Up to 3 months |
Why Choose Peptide Shop for Tirzepatide?
Verified Purity
Our Tirzepatide undergoes rigorous quality testing with ≥99% purity verified by HPLC. Mass spectrometry confirms identity, and comprehensive COAs accompany every order.
UK-Based Supply
- Fast UK delivery - No customs delays or import complications
- Next-day option available - For urgent research needs
- Temperature-controlled shipping - Maintains peptide integrity
- Discreet, professional packaging - All orders shipped securely
Research Support
Our technical team provides:
- Reconstitution guidance
- Storage recommendations
- Application advice
- Custom order assistance
Ordering Tirzepatide from Peptide Shop
Available Package Sizes
| Size | Recommended For |
|---|---|
| 5 mg | Pilot studies, method development |
| 10 mg | Standard research projects |
| 15 mg | Large-scale studies, extended research |
Bulk quantities available for institutional projects.
Delivery Options
- Express UK Delivery (1-2 working days): £12.99
- Standard UK Delivery (3-5 working days): £5.99
Research Use Statement
This product is sold exclusively for laboratory research purposes. Tirzepatide from Peptide Shop is not intended for human or veterinary use. This is not “Mounjaro” or any branded pharmaceutical - it is research-grade tirzepatide for in vitro and animal research conducted by qualified professionals.
Order Tirzepatide Today
Advance your dual incretin research with premium-quality Tirzepatide from Peptide Shop. Our commitment to purity, documentation, and service supports your most demanding research applications.
Minimum order: £200 | 10% discount on orders over £200
Select your package size above to add to cart. Contact our team for bulk pricing or custom requirements.
Product Specifications
| CAS Number | 2023788-19-2 |
|---|---|
| Molecular Weight | 4813.45 g/mol |
| Purity | ≥ 99% |
| Storage | -20°C recommended (research-only) |
| Available Sizes | 1 month pens |
| Price Range | £250 per month |
FAQ
Tirzepatide is a dual agonist that activates both GIP and GLP-1 receptors, while Semaglutide only targets the GLP-1 receptor. This dual mechanism of action provides researchers with a unique tool for studying the synergistic effects of incretin hormone signalling in metabolic research.
Tirzepatide is primarily used in metabolic research to study dual incretin receptor activation, glucose homeostasis, insulin secretion, and weight management mechanisms. Researchers investigate how the combined GIP/GLP-1 activity influences appetite, energy expenditure, and beta-cell function.
Lyophilised Tirzepatide should be stored at -20°C for optimal long-term stability. Once reconstituted with sterile water or appropriate buffer, store at 2-8°C and use within 4 weeks. Avoid repeated freeze-thaw cycles and protect from light exposure.
Our Tirzepatide is ≥99% pure as verified by HPLC analysis. Each batch includes a Certificate of Analysis (COA) with purity data, mass spectrometry identity confirmation, and peptide content analysis.
Reconstitute Tirzepatide in sterile bacteriostatic water or a suitable buffer at your desired concentration. Add solvent slowly along the vial wall and gently swirl to dissolve. Avoid vigorous shaking which can denature the peptide.
No. Mounjaro is the brand name for a prescription medication containing tirzepatide. Our product is the raw research-grade peptide sold exclusively for laboratory research purposes, not for human consumption or medical treatment.
Tirzepatide has an extended half-life of approximately 5 days due to its C20 fatty diacid modification that enables albumin binding. This prolonged duration of action is valuable for studying sustained dual receptor activation in research models.
Tirzepatide is available in 5mg, 10mg, and 15mg vials. Larger quantities are available for institutional research projects - contact us for bulk pricing on custom orders.
Customer Reviews (23)
Based on 23 reviews
Dr. Catherine Reynolds • 2024-12-18Verified Purchase
We're investigating GIP/GLP-1 synergy in our lab and this Tirzepatide has been perfect. Purity matches our reference standards and the results are highly reproducible. Fast UK delivery was a bonus.
Newcastle Metabolic Unit • 2024-12-12Verified Purchase
Switched from an overseas supplier to Peptide Shop and the quality difference is noticeable. Better solubility, consistent results, and no more customs delays. Highly recommend.
Mark Henderson • 2024-12-05Verified Purchase
The 10mg vials are perfect for our medium-scale studies. Quality is exceptional and the COA documentation is comprehensive. Will continue ordering from Peptide Shop.
Glasgow Diabetes Research • 2024-11-28Verified Purchase
Running a long-term study requiring consistent peptide quality. Peptide Shop has delivered every time. Their Tirzepatide performs identically across batches in our glucose tolerance studies.
Dr. Sarah Mitchell • 2024-11-22Verified Purchase
Excellent purity and activity. The only reason for 4 stars is I'd love to see a 2.5mg option for initial pilot studies. Product quality itself is top-notch.
Cambridge Incretin Lab • 2024-11-15Verified Purchase
After testing several suppliers, Peptide Shop offers the best combination of purity, price, and service for Tirzepatide research. Essential for our incretin mechanism studies.
James Phillips • 2024-11-08Verified Purchase
Ordered Friday afternoon, arrived Monday morning. Properly packaged with cold packs. Peptide dissolved easily and showed expected dual receptor activity. Perfect.
Liverpool University Lab • 2024-11-01Verified Purchase
Our beta-cell function studies require high-quality peptides and Peptide Shop delivers. The Tirzepatide shows expected effects in our islet preparations consistently.
Dr. William Turner • 2024-10-25Verified Purchase
Have placed multiple orders over six months. Always prompt delivery, always excellent quality. The 10% discount on larger orders helps our research budget.
Southampton Obesity Studies • 2024-10-18Verified Purchase
Using Tirzepatide in our diet-induced obesity models. Results are consistent with published literature using pharmaceutical-grade material. Excellent value.
Emma Richardson • 2024-10-12Verified Purchase
Quality is excellent for the price. Quick delivery to our lab. Would recommend to colleagues working in metabolic research.
Oxford Metabolic Group • 2024-10-05Verified Purchase
The COA includes everything we need for our quality records - HPLC, MS data, peptide content. Product quality matches the documentation perfectly.
Dr. Robert Clarke • 2024-09-28Verified Purchase
We verify all peptides in-house before use. Peptide Shop' Tirzepatide consistently exceeds purity claims. Worth the investment for serious research.
Edinburgh Biotech Lab • 2024-09-22Verified Purchase
Finally found a reliable UK source for research peptides. No import hassles, fast delivery, excellent quality. Our new preferred supplier for incretins.
Hannah Cooper • 2024-09-15Verified Purchase
Easy ordering process, prompt delivery, quality product. Customer service was helpful when I had questions about reconstitution. Will order again.
Manchester Incretin Research • 2024-09-08Verified Purchase
Using this for comparative studies with GLP-1 mono-agonists. The quality allows us to draw meaningful conclusions about dual receptor mechanisms.
Dr. Michael Barnes • 2024-09-01Verified Purchase
Excellent product for investigating the unique pharmacology of dual incretin agonism. Purity is exceptional and results are reproducible.
Bristol Research Centre • 2024-08-25Verified Purchase
From order to delivery, everything was professional. The Tirzepatide quality is excellent for our receptor binding assays. Five stars deserved.
Laura Martin • 2024-08-18Verified Purchase
Multiple orders over the past year and quality has been uniformly excellent. Essential for our ongoing research programme.
Cardiff Metabolic Studies • 2024-08-12Verified Purchase
Ran independent HPLC analysis - purity exceeded 99% as claimed. Few suppliers offer this level of quality with proper documentation.
Dr. Jennifer Adams • 2024-08-05Verified Purchase
Quality is excellent, delivery prompt. Minor suggestion: would appreciate even smaller trial sizes for initial experiments.
Leeds Hormone Lab • 2024-07-30Verified Purchase
Our incretin signalling studies require high-purity peptides. Peptide Shop consistently delivers. Tirzepatide performs perfectly in our assays.
Thomas Walker • 2024-07-25Verified Purchase
Express delivery lived up to its promise - ordered Tuesday, arrived Wednesday. Product quality was exactly as described.
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